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Differential influences of various arsenic compounds on antioxidant defense system in liver and kidney of rats

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10139601" target="_blank" >RIV/00216208:11140/13:10139601 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.etap.2013.09.003" target="_blank" >http://dx.doi.org/10.1016/j.etap.2013.09.003</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.etap.2013.09.003" target="_blank" >10.1016/j.etap.2013.09.003</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Differential influences of various arsenic compounds on antioxidant defense system in liver and kidney of rats

  • Original language description

    In this study, oxidative stress-related parameters and As retention were examined in liverand kidneys of male Wistar rats exposed to arsenic trioxide, sodium arsenite (iAsIII), sodiumarsenate (iAsV), and dimethylarsinic acid (DMAsV) at a single ip dose of 3.8 mg As/kg bw, at24 h post-exposure. In liver, lipid peroxidation increased in iAsIII-exposed rats, glutathioneperoxidase activity decreased in inorganic arsenic (iAs)-exposed rats, and catalase and thioredoxin reductase activities decreased significantly in all As-exposed groups. Both As(III) and As(V) exposure elevated GSH level with no effect on glutathione reductase activity. In kidneys, catalase activity decreased significantly in iAs-exposed, rats; GSH level, glutathione reductase and thioredoxin reductase activity decreased in DMAsV-treated, rats. The tissue As retention was higher in kidneys compared to liver and was also higher in As(III)-exposed compared to As(V)-exposed rats. The results demonstrate similar potency of ino

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Environmental Toxicology and Pharmacology

  • ISSN

    1382-6689

  • e-ISSN

  • Volume of the periodical

    36

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    7

  • Pages from-to

    1015-1021

  • UT code for WoS article

    000329530600033

  • EID of the result in the Scopus database