Differential influences of various arsenic compounds on antioxidant defense system in liver and kidney of rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10139601" target="_blank" >RIV/00216208:11140/13:10139601 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.etap.2013.09.003" target="_blank" >http://dx.doi.org/10.1016/j.etap.2013.09.003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.etap.2013.09.003" target="_blank" >10.1016/j.etap.2013.09.003</a>
Alternative languages
Result language
angličtina
Original language name
Differential influences of various arsenic compounds on antioxidant defense system in liver and kidney of rats
Original language description
In this study, oxidative stress-related parameters and As retention were examined in liverand kidneys of male Wistar rats exposed to arsenic trioxide, sodium arsenite (iAsIII), sodiumarsenate (iAsV), and dimethylarsinic acid (DMAsV) at a single ip dose of 3.8 mg As/kg bw, at24 h post-exposure. In liver, lipid peroxidation increased in iAsIII-exposed rats, glutathioneperoxidase activity decreased in inorganic arsenic (iAs)-exposed rats, and catalase and thioredoxin reductase activities decreased significantly in all As-exposed groups. Both As(III) and As(V) exposure elevated GSH level with no effect on glutathione reductase activity. In kidneys, catalase activity decreased significantly in iAs-exposed, rats; GSH level, glutathione reductase and thioredoxin reductase activity decreased in DMAsV-treated, rats. The tissue As retention was higher in kidneys compared to liver and was also higher in As(III)-exposed compared to As(V)-exposed rats. The results demonstrate similar potency of ino
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental Toxicology and Pharmacology
ISSN
1382-6689
e-ISSN
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Volume of the periodical
36
Issue of the periodical within the volume
3
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
1015-1021
UT code for WoS article
000329530600033
EID of the result in the Scopus database
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