Fate of two types of cerebellar graft in wild type and cerebellar mutant mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10156021" target="_blank" >RIV/00216208:11140/14:10156021 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1214021X13000021#" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1214021X13000021#</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jab.2013.03.001" target="_blank" >10.1016/j.jab.2013.03.001</a>

Result language
angličtina
Original language name
Fate of two types of cerebellar graft in wild type and cerebellar mutant mice
Original language description
The possibility of regeneration in a damaged central nervous system (CNS) is limited and therapy of CNS diseases accompanied with neuronal loss is problematic. Neurotransplantation-based therapies have a great potential for future treatments of various diseases, not only by replacing missing or malfunctioning cells but mainly by supporting the inner regenerative processes. Lurcher (Lc) mutant mice represent a model for olivocerebellar degeneration. Heterozygotes suffer from a complete loss of cerebellarPurkinje cells and a secondary reduction of granule cells and inferior olive neuron number. The aim of this study was to analyze the survival potential and appearance of grafted GFP-positive carcinoma stem cells partially differentiated into neuroprogenitors from the P19 line or cerebellar embryonic tissue (in the form of cell suspension) both transplanted into the cerebellum of Lurcher mutant and healthy control wild type mice.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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