Neither expression of VEGF-C/D nor lymph nvessel density supports lymphatic invasion as the mechanism responsible for local spread of recurrent salivary pleomorphic adenoma

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10189740" target="_blank" >RIV/00216208:11140/14:10189740 - isvavai.cz</a>
Result on the web
<a href="http://download.springer.com/static/pdf/968/art%253A10.1007%252Fs00428-013-1502-5.pdf?auth66=1391250642_74d5bb3d7d7c87b81e95adb3ac8a4dde&ext=.pdf" target="_blank" >http://download.springer.com/static/pdf/968/art%253A10.1007%252Fs00428-013-1502-5.pdf?auth66=1391250642_74d5bb3d7d7c87b81e95adb3ac8a4dde&ext=.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00428-013-1502-5" target="_blank" >10.1007/s00428-013-1502-5</a>

Result language
angličtina
Original language name
Neither expression of VEGF-C/D nor lymph nvessel density supports lymphatic invasion as the mechanism responsible for local spread of recurrent salivary pleomorphic adenoma
Original language description
Recent research suggests that multinodular recurrent pleomorphic adenoma (PA) might result from cell migration through lymphatics. Lymphangiogenesis in malignancies is mediated by vascular endothelial growth factors C and D (VEGF-C/D). We studied the expression of VEGF-C/D in PA by immunohistochemistry as well as lymphatic vessel density (LVD). In 6 non-recurrent, 4 primary-to-recur, and 10 recurrent PAs, VEGF-C/D expression was assessed by immunohistochemistry. Staining was scored in terms of stainingintensity (0 = absent to 3 = strong), and the percentage of positive tumor cells (scored as 0 (0-19 %), 1 (20-39 %), 2 (40-50 %), and 3 (60-100 %)) and a sum score were calculated. Intra- and peritumoral LVD was assessed by counting of LV after immunostaining, using the D2-40 antibody. All but one sample were VEGF-C negative. The differences in VEGF-D expression between non-recurrent, primary-to-recur, and recurrent PAs were not significant (p > 0.05). VEGF-D expression did not correlate
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
<a href="/en/project/NT13701" target="_blank" >NT13701: Expression of vascular endothelial growth factor VEGF-C/D and its significance for lymphangioneogenesis, nodal metastase and prognosis of salivary gland carcinomas.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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