Expanded cryopreserved mesenchymal stromal cells as an optimal source for graft-versus-host disease treatment

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10218654" target="_blank" >RIV/00216208:11140/14:10218654 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/14:00435673 RIV/00669806:_____/14:10218654
Result on the web
<a href="http://dx.doi.org/10.1016/j.biologicals.2014.01.003" target="_blank" >http://dx.doi.org/10.1016/j.biologicals.2014.01.003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biologicals.2014.01.003" target="_blank" >10.1016/j.biologicals.2014.01.003</a>

Result language
angličtina
Original language name
Expanded cryopreserved mesenchymal stromal cells as an optimal source for graft-versus-host disease treatment
Original language description
Mesenchymal stromal cells (MSC) are fibroblast-like cells present in different types of tissues. Their immunomodulatory potential represents a promising method for post-transplant immunotherapy in the treatment of GVHD (graft-versus-host disease) with suboptimal response to standard immunosuppression. In this study we tested influence of 1e8 month-long cryopreservation on ability of MSC to suppress activation of non-specifically stimulated lymphocytes. We did not observe any changes in proliferation capacity of MSC after thawing. Lymphocytes metabolic activity was inhibited by 30% and number of dividing cells was three times smaller in the presence of MSC. Two activation markers were studied (CD25 and CD69) to confirm preservation of functional cell integrity. Expression of CD25 antigen on CD3ţCD4ţ and CD3ţCD4 cells was decreased in all cocultivated samples. Level of CD69 expression on CD3ţCD4ţ cells was lower in samples with added MSC (10e15% on day ţ2) but without reaching statistica
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/ED2.1.00%2F03.0076" target="_blank" >ED2.1.00/03.0076: Biomedical Centre of the Faculty of Medicine in Pilsen</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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