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Discovery and Diagnostic Value of a Novel Oncofetal Protein: Glypican 3

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10284094" target="_blank" >RIV/00216208:11140/14:10284094 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1097/PAP.0000000000000043" target="_blank" >http://dx.doi.org/10.1097/PAP.0000000000000043</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1097/PAP.0000000000000043" target="_blank" >10.1097/PAP.0000000000000043</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Discovery and Diagnostic Value of a Novel Oncofetal Protein: Glypican 3

  • Original language description

    Glypican 3 is a membrane-bound heparan sulfate proteoglycan, which has recently been identified as a marker for liver cancer and germ cell malignancies. Individuals with loss-of-function mutations for the glypican 3 gene exhibit Simpson-Golabi-Behmel syndrome, a rare X-linked overgrowth disorder. Expression of glypican 3 mRNA and protein is normally silenced in most adult organs and may reappear during malignant transformation. In the past few years, immunohistochemical and molecular characteristics ofglypican 3 in hepatocellular carcinoma have been elucidated. More recently, glypican 3 has been emerging as a new diagnostic marker for germ cell tumors and especially testicular and ovarian yolk sac tumors. However, in other tumors such as renal cell carcinomas, squamous cell carcinomas, and melanomas, studies disagree on the level of glypican 3 expression. Finally, there is the controversial notion of glypican 3 as a tumor suppressor gene. In this review article, we update current know

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FP - Other medical fields

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Advances in Anatomic Pathology

  • ISSN

    1072-4109

  • e-ISSN

  • Volume of the periodical

    21

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    450-460

  • UT code for WoS article

    000344252100007

  • EID of the result in the Scopus database