Discovery and Diagnostic Value of a Novel Oncofetal Protein: Glypican 3
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10284094" target="_blank" >RIV/00216208:11140/14:10284094 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1097/PAP.0000000000000043" target="_blank" >http://dx.doi.org/10.1097/PAP.0000000000000043</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/PAP.0000000000000043" target="_blank" >10.1097/PAP.0000000000000043</a>
Alternative languages
Result language
angličtina
Original language name
Discovery and Diagnostic Value of a Novel Oncofetal Protein: Glypican 3
Original language description
Glypican 3 is a membrane-bound heparan sulfate proteoglycan, which has recently been identified as a marker for liver cancer and germ cell malignancies. Individuals with loss-of-function mutations for the glypican 3 gene exhibit Simpson-Golabi-Behmel syndrome, a rare X-linked overgrowth disorder. Expression of glypican 3 mRNA and protein is normally silenced in most adult organs and may reappear during malignant transformation. In the past few years, immunohistochemical and molecular characteristics ofglypican 3 in hepatocellular carcinoma have been elucidated. More recently, glypican 3 has been emerging as a new diagnostic marker for germ cell tumors and especially testicular and ovarian yolk sac tumors. However, in other tumors such as renal cell carcinomas, squamous cell carcinomas, and melanomas, studies disagree on the level of glypican 3 expression. Finally, there is the controversial notion of glypican 3 as a tumor suppressor gene. In this review article, we update current know
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advances in Anatomic Pathology
ISSN
1072-4109
e-ISSN
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Volume of the periodical
21
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
450-460
UT code for WoS article
000344252100007
EID of the result in the Scopus database
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