Testicular Cancer from Diagnosis to Epigenetic Factors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F17%3A00327980" target="_blank" >RIV/68407700:21460/17:00327980 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/17:10373482 RIV/68407700:21720/17:00327980
Result on the web
<a href="https://doi.org/10.18632/oncotarget.20992" target="_blank" >https://doi.org/10.18632/oncotarget.20992</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.18632/oncotarget.20992" target="_blank" >10.18632/oncotarget.20992</a>
Alternative languages
Result language
angličtina
Original language name
Testicular Cancer from Diagnosis to Epigenetic Factors
Original language description
Testicular cancer (TC) is one of the most common neoplasms that occurs in male and includes germ cell tumors (GCT), sex cord-gonadal stromal tumors and secondary testicular tumors. Diagnosis of TC involves the evaluation of serum tumor markers alpha-fetoprotein, human chorionic gonadotropin and lactate dehydrogenase, but clinically several types of immunohistochemical markers are more useful and more sensitive in GCT, but not in teratoma. These new biomarkers are genes expressed in primordial germ cells/gonocytes and embryonic pluripotency-related cells but not in normal adult germ cells and they include PLAP, OCT3/4 (POU5F1), NANOG, SOX2, REX1, AP-2γ (TFAP2C) and LIN28. Gene expression in GCT is regulated, at least in part, by DNA and histone modifications, and the epigenetic profile of these tumours is characterised by genome-wide demethylation. There are different epigenetic modifications in TG-subtypes that reflect the normal developmental switch in primordial germ cells from an under- to normally methylated genome. The main purpose of this review is to illustrate the findings of recent investigations in the classification of male genital organs, the discoveries in the use of prognostic and diagnostic markers and the epigenetic aberrations mainly affecting the patterns of DNA methylation/histone modifications of genes (especially tumor suppressors) and microRNAs (miRNAs).
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30402 - Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)
Result continuities
Project
<a href="/en/project/ED2.1.00%2F03.0091" target="_blank" >ED2.1.00/03.0091: University center for energy Efficient buildings (UCEEB)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oncotarget
ISSN
1949-2553
e-ISSN
1949-2553
Volume of the periodical
8
Issue of the periodical within the volume
61
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
104654-104663
UT code for WoS article
000419562500151
EID of the result in the Scopus database
2-s2.0-85035331570