CD30+clonal T-cell lymphoid proliferation of the skin in a patient with hypereosinophilic syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10295080" target="_blank" >RIV/00216208:11140/15:10295080 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/cup.12454" target="_blank" >http://dx.doi.org/10.1111/cup.12454</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/cup.12454" target="_blank" >10.1111/cup.12454</a>
Alternative languages
Result language
angličtina
Original language name
CD30+clonal T-cell lymphoid proliferation of the skin in a patient with hypereosinophilic syndrome
Original language description
We report a hitherto undescribed unusual CD30+ clonal T-cell proliferation in a 46-year-old man with the lymphocytic variant of hypereosinophilic syndrome with a 17-year history of pruritus, generalized persistent papulonodular skin lesions and peripheral blood hypereosinophilia. A skin biopsy showed an eosinophil-rich infiltrate with small to medium-sized CD30+ lymphocytes and Churg-Strauss granulomas. Peripheral blood flow cytometry revealed an aberrant T-cell clone which, molecular genetically, was identical to the T-cell clone detected in the skin. No genetic aberrations of platelet-derived growth factor receptor alpha (PDGFRA), FIP1L1-PDGFRA, PDGFRB or FGFR1 were found. The skin lesions showed transient response to systemic and topical corticosteroids. The skin lesions represent cutaneous involvement by clonal T-cells in hypereosinophilic syndrome and differ from known cutaneous CD30+ lymphoproliferative disorders.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cutaneous Pathology
ISSN
0303-6987
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
2
Country of publishing house
DK - DENMARK
Number of pages
6
Pages from-to
130-135
UT code for WoS article
000350055700007
EID of the result in the Scopus database
2-s2.0-84923295078