DEFECTIVE TCR SURFACE EXPRESSION ASSOCIATED WITH IMPAIRED TCR BETA-CHAIN ASSEMBLY IN A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F95%3A00035802" target="_blank" >RIV/00216224:14110/95:00035802 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

DEFECTIVE TCR SURFACE EXPRESSION ASSOCIATED WITH IMPAIRED TCR BETA-CHAIN ASSEMBLY IN A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA

Original language description

We report on a patient with cutaneous T-cell lymphoma (CTCL) of long-standing duration. Phenotypic analysis of his peripheral blood mononuclear cells revealed an increased CD4(+) T-helper subset and a decreased CD8(+) cytotoxic T-cell population. Eighty-three to ninety-three percent of the patient's CD4(+) T cells in the peripheral blood and 70% of the CD4(+) T cells in the lesional skin lacked surface expression of the TCR/CD3 complex and showed a clonal rearrangement pattern of the TCR gamma-chain gene (V11-J1/J2). The lack in TCR surface expression correlated with defective assembly of the TCR beta-chain. Although mRNA for the TCR constant region beta 1 was found in the patient's purified CD4(+)TCR(-)CD3(-) T cells, no intracytoplasmic TCR beta protein was detectable. In contrast, the patient's purified CD4(+)TCR(-)CD3(-) T cells not only expressed mRNA specific for the TCR alpha-chain and for all CD3 chains, but intracytoplasmic TCR alpha and CD3 epsilon proteins could also be foun

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

—

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

1995

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF INVESTIGATIVE DERMATOLOGY

ISSN

0022-202X

e-ISSN

—

Volume of the periodical

104

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

—

UT code for WoS article

A1995QR53200021

EID of the result in the Scopus database

—