T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F11%3A00371708" target="_blank" >RIV/68378050:_____/11:00371708 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.molimm.2011.03.021" target="_blank" >http://dx.doi.org/10.1016/j.molimm.2011.03.021</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.molimm.2011.03.021" target="_blank" >10.1016/j.molimm.2011.03.021</a>

Result language

angličtina

Original language name

T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner

Original language description

Death receptor-6 (DR6) participates in the regulation of T-cell activation and/or activity as its genetic disruption results in enhanced CD4+ T-cell expansion, the production of Th2 cytokines, and interestingly also the compromised migration of CD4+ T cells to sites of inflammation. In this communication we show that DR6 is not expressed in resting T cells from human peripheral blood or murine lymph nodes but that its expression is significantly upregulated in CD3 crosslinking- or PMA/ionomycin-activated T lymphocytes. DR6 expression is transiently increased in both activated human CD4+ and CD8+ T cells and it is apparently dependent on the activation of NF-kappaB and NF-AT signaling pathways. In contrast to primary peripheral blood T cells, the widelyused model lymphoblastic leukemia T-cell line Jurkat is DR6-positive and unexpectedly, TCR-mediated stimulation of Jurkat cells strongly downregulates DR6 expression via suppression of its transcription.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/1M0506" target="_blank" >1M0506: Center of Molecular and Cellular Immunology</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Immunology

ISSN

0161-5890

e-ISSN

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Volume of the periodical

48

Issue of the periodical within the volume

12

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

1439-1447

UT code for WoS article

000292444100011

EID of the result in the Scopus database

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