Numbers of CD8 PD-1 and CD4 PD-1 Cells in Peripheral Blood of Patients with Chronic Lymphocytic Leukemia Are Independent of Binet Stage and Are Significantly Higher Compared to Healthy Volunteers

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33154252" target="_blank" >RIV/61989592:15110/15:33154252 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/15:#0000923
Result on the web
<a href="http://dx.doi.org/10.1159/000381468" target="_blank" >http://dx.doi.org/10.1159/000381468</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1159/000381468" target="_blank" >10.1159/000381468</a>

Result language
angličtina
Original language name
Numbers of CD8 PD-1 and CD4 PD-1 Cells in Peripheral Blood of Patients with Chronic Lymphocytic Leukemia Are Independent of Binet Stage and Are Significantly Higher Compared to Healthy Volunteers
Original language description
The programmed cell death pathway is involved in functional impairment of cytotoxic CD8+ T cells in chronic viral infection and in tumor immune evasion. The interaction of programmed cell death-1 (PD-1) with its ligand suppresses antitumor T cell function and stimulates the regulatory T cell population. The objectives were to investigate whether examining PD-1 expression in peripheral T cells of patients with chronic lymphocytic leukemia (CLL) reflected the disease phase and Binet stage and to compare the results with those in healthy volunteers. The study analyzed peripheral blood from previously untreated patients with CLL, patients with relapsed or refractory disease under treatment and healthy blood donors using flow cytometry. PD-1 expression in peripheral blood CD4+ and CD8+ cells was markedly different between disease stages and in comparison with healthy subjects. The highest numbers of both CD8+PD-1+ and CD4+PD-1+ cells were present in patients with relapsed/refractory disease
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
—

Project
<a href="/en/project/NT13576" target="_blank" >NT13576: Integrated genomic analysis of chronic lymphocytic leukemia (CLL) for genetic and clinical identification of subgroups with aberrations of selected chromosomes.</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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