PRR7 Is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F11%3A00365069" target="_blank" >RIV/68378050:_____/11:00365069 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1074/jbc.M110.175117" target="_blank" >http://dx.doi.org/10.1074/jbc.M110.175117</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1074/jbc.M110.175117" target="_blank" >10.1074/jbc.M110.175117</a>
Alternative languages
Result language
angličtina
Original language name
PRR7 Is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis
Original language description
A highly conserved ransmembrane adaptor protein (TRAP) PRR7 was found to be readily up-regulated in activated human peripheral blood lymphocytes. Transient overexpression of PRR7 in Jurkat T cell line led to gradual apoptotic death dependent on the WW domain binding motif surrounding Tyr-166 in the intracellular part of PRR7. Jurkat clones with inducible expression of PRR7 (J-iPRR7) were generated. In these cells acute induction of PRR7 expression had a dual effect. It resulted in up-regulation of the transcription factor c-Jun and the activation marker CD69 as well as enhanced production of IL-2 after phorbol 12-myristate 13-acetate (PMA) and ionomycin treatment. Expression of PRR7 inhibited general tyrosine phosphorylation and calcium influx after Tcell receptor cross-linking by antibodies. PRR7 was constitutively tyrosine-phosphorylated and associated with Src. PRR7 is a potential regulator of signaling and apoptosis in activated T cells.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/1M0506" target="_blank" >1M0506: Center of Molecular and Cellular Immunology</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biological Chemistry
ISSN
0021-9258
e-ISSN
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Volume of the periodical
286
Issue of the periodical within the volume
22
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
19617-19629
UT code for WoS article
000291027700045
EID of the result in the Scopus database
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