Transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F01%3A23010293" target="_blank" >RIV/68378050:_____/01:23010293 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.

Original language description

Adaptor protein TRIM preferentially interacts with the TCRvia the TCR-y and CD3-eg. Overexpression of TRIM cells results in enhancement of TCR expression and elevated induction of Ca(2+) mobilization. TRIM-mediated upregulation of TCR expression resultsfrom inhibition of spontaneous TCR internalization of TCR complexes on the cell surface. TRIM is a novel component of the TCR complex modulating the strength of TCR signals through regulation of TCR expression on the cell surface.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GA204%2F99%2F0367" target="_blank" >GA204/99/0367: Molecular mechanisms of signalling through immunoreceptors</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Experimental Medicine

ISSN

0022-1007

e-ISSN

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Volume of the periodical

193

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

1269-1283

UT code for WoS article

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EID of the result in the Scopus database

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