Microsomal epoxide hydrolase 1 (EPHX1): Gene, structure, function, and role in human disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10306820" target="_blank" >RIV/00216208:11140/15:10306820 - isvavai.cz</a>
Alternative codes found
RIV/75010330:_____/15:00010916
Result on the web
<a href="http://dx.doi.org/10.1016/j.gene.2015.07.071" target="_blank" >http://dx.doi.org/10.1016/j.gene.2015.07.071</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.gene.2015.07.071" target="_blank" >10.1016/j.gene.2015.07.071</a>

Result language
angličtina
Original language name
Microsomal epoxide hydrolase 1 (EPHX1): Gene, structure, function, and role in human disease
Original language description
Microsomal epoxide hydrolase (EPHX1) is an evolutionarily highly conserved biotransformation enzyme for converting epoxides to diols. Notably, the enzyme is able to either detoxify or bioactivate a wide range of substrates. Mutations and polymorphic variants in the EPHX1 gene have been associated with susceptibility to several human diseases including cancer. This review summarizes the key knowledge concerning EPHX1 gene and protein structure, expression pattern and regulation, and substrate specificity. The relevance of EPHX1 for human pathology is especially discussed.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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