Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10311894" target="_blank" >RIV/00216208:11140/15:10311894 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/15:00059387
Result on the web
<a href="http://dx.doi.org/10.1186/s12882-015-0141-2" target="_blank" >http://dx.doi.org/10.1186/s12882-015-0141-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12882-015-0141-2" target="_blank" >10.1186/s12882-015-0141-2</a>

Result language
angličtina
Original language name
Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance
Original language description
Background: Induction therapy can improve kidney transplantation (KTx) outcomes, but little is known about the mechanisms underlying its effects. Methods: The mRNA levels of T cell-related genes associated with tolerance or rejection (CD247, GZMB, PRF1,FOXP3, MAN1A1, TCAIM, and TLR5) and lymphocyte subpopulations were monitored prospectively in the peripheral blood of 60 kidney transplant recipients before and 7, 14, 21, 28, 60, 90 days, 6 months, and 12 months after KTx. Patients were treated with calcineurin inhibitor-based triple immunosuppression and induction with rabbit antithymocyte globulin (rATG, n = 24), basiliximab (n = 17), or without induction (no-induction, n = 19). A generalized linear mixed model with gamma distribution for repeated measures, adjusted for rejection, recipient/donor age and delayed graft function, was used for statistical analysis. Results: rATG treatment caused an intense reduction in all T cell type population and natural killer (NK) cells within 7 da
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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