Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059387" target="_blank" >RIV/00023001:_____/15:00059387 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/15:10311894
Result on the web
<a href="http://www.biomedcentral.com/content/pdf/s12882-015-0141-2.pdf" target="_blank" >http://www.biomedcentral.com/content/pdf/s12882-015-0141-2.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12882-015-0141-2" target="_blank" >10.1186/s12882-015-0141-2</a>

Result language
angličtina
Original language name
Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance
Original language description
Background: Induction therapy can improve kidney transplantation (KTx) outcomes, but little is known about the mechanisms underlying its effects. Methods: The mRNA levels of T cell-related genes associated with tolerance or rejection (CD247, GZMB, PRF1, FOXP3, MAN1A1, TCAIM, and TLR5) and lymphocyte subpopulations were monitored prospectively in the peripheral blood of 60 kidney transplant recipients before and 7, 14, 21, 28, 60, 90 days, 6 months, and 12 months after KTx. Patients were treated with calcineurin inhibitor-based triple immunosuppression and induction with rabbit antithymocyte globulin (rATG, n = 24), basiliximab (n = 17), or without induction (no-induction, n = 19). A generalized linear mixed model with gamma distribution for repeated measures, adjusted for rejection, recipient/donor age and delayed graft function, was used for statistical analysis. Conclusion: The rATG induction therapy was associated with decreased T and NK cell-related transcript levels and with upregulation of two rejection-associated transcripts (MAN1A1 and TLR5) shortly after KTx. Basiliximab treatment was associated with increased absolute number of Treg cells, and increased level of FOXP3 and TCAIM expression.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30213 - Transplantation

Project
<a href="/en/project/7E13020" target="_blank" >7E13020: Personalized minimization of immunosuppression after solid organ transplantation by biomarker-driven stratification of patients to improve long-term outcome and health-economic data of transplantation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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