SOX10 and Olig2 as negative markers fot the diagnosis of ependymomas: An immunohistochemical study of 98 glial tumors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F16%3A10314625" target="_blank" >RIV/00216208:11140/16:10314625 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.14670/HH-11-654" target="_blank" >http://dx.doi.org/10.14670/HH-11-654</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14670/HH-11-654" target="_blank" >10.14670/HH-11-654</a>

Result language

angličtina

Original language name

SOX10 and Olig2 as negative markers fot the diagnosis of ependymomas: An immunohistochemical study of 98 glial tumors

Original language description

SOX10 belongs to the family of transcription factors essential for the development of neural crest, peripheral nervous system and melanocytes. It is presently used in histopathology as a marker of melanocytic differentiation. SOX10 is expressed in normal brain tissue in oligodendrocytes, but the information about SOX10 expression in primary tumors of the central nervous system is quite limited. In this study, we examined the expression of SOX10 and Olig2 by immunohistochemistry in a series of 98 glial tumors and explored their specificity and sensitivity for differential diagnosis of ependymal vs non-ependymal tumors. In addition, we examined the expression of EMA and CD99 in ependymal tumors. SOX10 and Olig2 staining were scored as negative if no positive cells or only a few positive cells (typically up to 1-3%) were found. In all other instances, SOX10 or Olig2 staining was scored as positive. Out of 44 examined ependymal tumors none was found to express SOX10 and 7 specimens showed only a few SOX10-positive cells that likely corresponded to entrapped nonneoplastic oligodendrocytes. In contrast, non-ependymal tumors expressed SOX10 in 26/54 (48%) specimens. Olig2 was positive in 5 out of 44 ependymomas (11%) and 50 out of 54 (93%) non-ependymal tumors (astrocytomas and oligodendrogliomas). EMA and CD99 expression was found in 33/44 (75%) and 11/44 (25%) of ependymomas, respectively. SOX10-positivity rules out the diagnosis of ependymoma among other glial tumors with high confidence.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

—

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Histology and Histopathology

ISSN

0213-3911

e-ISSN

—

Volume of the periodical

31

Issue of the periodical within the volume

1

Country of publishing house

ES - SPAIN

Number of pages

8

Pages from-to

95-102

UT code for WoS article

000366337900009

EID of the result in the Scopus database

2-s2.0-84949034141