Advances in Experimental Targeted Therapy and Immunotherapy for Patients with Glioblastoma Multiforme

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10330256" target="_blank" >RIV/00216208:11140/17:10330256 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/17:10330256

Result on the web

<a href="http://ar.iiarjournals.org/content/37/1/21.long" target="_blank" >http://ar.iiarjournals.org/content/37/1/21.long</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21873/anticanres.11285" target="_blank" >10.21873/anticanres.11285</a>

Result language

angličtina

Original language name

Advances in Experimental Targeted Therapy and Immunotherapy for Patients with Glioblastoma Multiforme

Original language description

Glioblastoma multiforme (GBM) represents the most malignant primary brain tumor in adults with generally dismal prognosis, early clinical deterioration and high mortality. GBM is extremely invasive, characterized by intense and aberrant vascularization and high resistance to multimodal treatment. Standard therapy (surgery, radiotherapy and chemotherapy with temozolomide) has very limited effectiveness, with median overall survival of patients no longer than 15 months. Progress in genetics and epigenetics of GBM over the past decade has revealed various aberrations in cellular signaling pathways, the tumor microenvironment, and pathological angiogenesis. A number of targeted anticancer drugs, such as small-molecule kinase inhibitors and monoclonal antibodies, have been evaluated in clinical trials with newly-diagnosed, as well as recurrent GBM. Unfortunately, to date, only a single anti-angiogenic agent, bevacizumab, has been approved for the treatment of recurrent GBM in the USA and Canada. The novel possibilities of cancer immunotherapy, especially immune checkpoint inhibitors, are being evaluated in clinical trials of patients with GBM. The most recent clinical experiences with targeted therapy as well as immunotherapy of GBM are given in this review. The relative lack of success of some of these approaches recently revealed in well-designed randomized clinical trials is also discussed.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

<a href="/en/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anticancer Research

ISSN

0250-7005

e-ISSN

—

Volume of the periodical

37

Issue of the periodical within the volume

1

Country of publishing house

GR - GREECE

Number of pages

13

Pages from-to

21-33

UT code for WoS article

000391958800004

EID of the result in the Scopus database

2-s2.0-85007580039