Bizarre cell dysplasia of the cervix
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10336513" target="_blank" >RIV/00216208:11140/17:10336513 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/17:10336513
Result on the web
<a href="http://dx.doi.org/10.1111/jog.13196" target="_blank" >http://dx.doi.org/10.1111/jog.13196</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jog.13196" target="_blank" >10.1111/jog.13196</a>
Alternative languages
Result language
angličtina
Original language name
Bizarre cell dysplasia of the cervix
Original language description
Aim: The aim of this study was the characterization of a new subtype of high-grade cervical squamous intraepithelial lesion (HSIL) with enlarged cells containing bizarre nuclei: so-called bizarre cell dysplasia (BCD). Methods: A total of 29 cervical cone biopsy samples of this type of dysplasia were studied. Multi-target polymerase chain reaction and in situ hybridization human papillomavirus (HPV) detection was performed in all cases. BCD was defined as a subtype of HSIL characterized by the presence of large dysplastic cells with abnormal, large pleomorphic nuclei or multinucleation causing nucleomegaly. This results in bizarre nuclear shapes. Bizarre cells are scattered throughout the whole thickness of the dysplastic squamous epithelium. Results: The BCD lesions arise within the conventional/classic high grade or "bland" type squamous dysplasia HSIL. Statistically they were significantly associated with HVP type 16. A significant association with other studied viruses (Herpes simplex virus [HSV]1, HSV2, Varicella zoster virus, Epstein-Barr virus, cytomegalovirus, human herpesvirus 6, and human polyomaviruses BK and JC) was not confirmed. Conclusions: BCD involves cytologically characteristic morphologic changes that are recognizable, but which may pose some risk of misdiagnosis as low-grade squamous intraepithelial lesion due to the enlargement of dysplastic cells and multinucleation. Based on the unique histological, cytological and biological features of BCD including strong associationwithHPV 16 infection, we believe that this is a specific, and so far unrecognized variant of HSIL.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Obstetrics and Gynaecology Research
ISSN
1341-8076
e-ISSN
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Volume of the periodical
43
Issue of the periodical within the volume
2
Country of publishing house
JP - JAPAN
Number of pages
7
Pages from-to
345-351
UT code for WoS article
000394675900013
EID of the result in the Scopus database
2-s2.0-85010951463