Significance of bizarre cells in cervical screening liquid-based cytology: A prospective study of 15 cases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10368899" target="_blank" >RIV/00216208:11140/18:10368899 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/18:10368899

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1111/cyt.12494/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/cyt.12494/epdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/cyt.12494" target="_blank" >10.1111/cyt.12494</a>

Result language

angličtina

Original language name

Significance of bizarre cells in cervical screening liquid-based cytology: A prospective study of 15 cases

Original language description

Objective: The aim of this study was to assess the significance of bizarre cells (cellsof squamous origin with a superficial squamous cell-type cytoplasm and charac-terised by multinucleation that produces bizarre nuclear shapes) in liquid- basedcytology (LBC) Papanicoaou (pap) smears with clinical and histological follow-upcorrelation.Methods: Fifteen patients, all with LBC samples containing bizarre cells, were iden-tified in routine ThinPrepâLBC workload. HPV testing was performed in each caseusing residual LBC material. Cytological-histological correlations were reviewed.Results: All 15 LBC samples contained bizarre cells and tested positive for high-riskHPV types. Ten of the 15 cases were identified as atypical squamous cells - cannotexclude an HSIL (ASC-H) with secondary diagnosis of low-grade squamous intraep-ithelial lesion (LSIL), while five cases were identified as high-grade squamous intra-epithelial lesion (HSIL), and a subsequent biopsy was recommended. Additionally,13/15 cases underwent cone biopsy or hysterectomy within 1-11 months, of which10 showed histologically confirmed HSIL end-points. LSIL was present in threecases. Bizarre cells were identified in the HSIL epithelium of five cone biopsies.Conclusions: Identification of bizarre cells in LBC is straightforward and mayfacilitate diagnosis. The cytology of bizarre cells is associated with HSIL in conebiopsies. We recommend assigning LBC samples containing bizarre cells as ASC-Hwith secondary diagnosis of LSIL.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30109 - Pathology

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cytopathology

ISSN

0956-5507

e-ISSN

—

Volume of the periodical

29

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

58-62

UT code for WoS article

000419968600008

EID of the result in the Scopus database

2-s2.0-85034569268