Antiretrovirals, Fractures, and Osteonecrosis in a Large International HIV Cohort
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10359630" target="_blank" >RIV/00216208:11140/17:10359630 - isvavai.cz</a>
Result on the web
<a href="https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/cix167" target="_blank" >https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/cix167</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/cid/cix167" target="_blank" >10.1093/cid/cix167</a>
Alternative languages
Result language
angličtina
Original language name
Antiretrovirals, Fractures, and Osteonecrosis in a Large International HIV Cohort
Original language description
Background: Antiretrovirals (ARVs) affect bone density and turnover, but their effect on risk of fractures and osteonecrosis of the femoral head is less understood. We investigated if exposure to ARVs increases the risk of both bone outcomes. Methods: EuroSIDA participants were followed to assess fractures and osteonecrosis. Poisson regression identified clinical, laboratory and demographic predictors of either bone outcome. Ever, current and cumulative exposures to ARVs were assessed. . Results: During 86118 PYFU among 11820 included persons (median age 41y, 75% male, median baseline CD4 440/mm3, 70.4% virologically suppressed), there were 619 fractures (incidence/1000PYFU 7.2; 95%CI 6.6-7.7) and 89 osteonecrosis (1.0;0.8-1.3). Older age, white race, lower BMI, IV drug use, lower baseline CD4, HCV-coinfection, prior osteonecrosis, prior fracture, cardiovascular disease and recent non-AIDS cancer (last 12 months) were associated with fractures. After adjustment, persons who had ever used Tenofovir Disoproxil Fumarate (TDF) (1.40; 1.15-1.70) or who were currently on TDF (1.25; 1.05-1.49) had higher incidence of fractures. There was no association between cumulative exposure to TDF and fractures (1.08/5y exposure; 0.94-1.25). No other ARV was associated with fractures (all p>0.1). Risk of osteonecrosis was associated with white race, lower nadir CD4, prior osteonecrosis, prior fracture and prior AIDS. After mutual adjustment, no ARV was associated with osteonecrosis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Infectious Diseases
ISSN
1058-4838
e-ISSN
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Volume of the periodical
64
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1413-1421
UT code for WoS article
000400912500017
EID of the result in the Scopus database
2-s2.0-85019104735