Plasma HIV-1 Tropism and the Risk of Short-Term Clinical Progression to AIDS or Death
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10359711" target="_blank" >RIV/00216208:11140/17:10359711 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0166613" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0166613</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0166613" target="_blank" >10.1371/journal.pone.0166613</a>
Alternative languages
Result language
angličtina
Original language name
Plasma HIV-1 Tropism and the Risk of Short-Term Clinical Progression to AIDS or Death
Original language description
Objective To investigate if plasma HIV-1 tropism testing could identify subjects at higher risk for clinical progression and death in routine clinical management. Design Nested case-control study within the EuroSIDA cohort. Methods Cases were subjects with AIDS or who died from any cause, with a plasma sample with HIV-1 RNA >1000 copies/mL available for tropism testing 3 to 12 months prior to the event. At least 1 control matched for age, HIV-1 RNA and HCV status at the time of sampling were selected per each case. Conditional logistic regression was used to investigate exposures associated with clinical progression to AIDS or death. A linear mixed model with random intercept was used to compare CD4(+)T-cell slopes by HIV tropism over the 12 months following the date of sampling. Results The study included 266 subjects, 100 cases and 166 controls; one quarter had X4 HIV; 26% were ART-naive. Baseline factors independently associated with clinical progression or death were female gender (OR=2.13 vs. male, 95CI = 1.04, 4.36), p = 0.038), CD4(+)T-cell count (OR = 0.90 (95CI = 0.80, 1.00) per 100 cells/mm 3 higher, p = 0.058), being on ART (OR = 2.72 vs. being off-ART (95CI = 1.15, 6.41), p = 0.022) and calendar year of sample [OR = 0.84 (95CI = 0.77, 0.91) per more recent year, p<0.001). Baseline tropism was not associated with the risk of clinical progression or death. CD4(+)T-cell slopes did not differ within or between tropism groups. Conclusions The predictive role of plasma tropism determined using 454 sequencing in the context of people receiving cART with detectable VL is not helpful to identify subjects at higher risk for clinical progression to AIDS or death.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS One
ISSN
1932-6203
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
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UT code for WoS article
000396211400074
EID of the result in the Scopus database
2-s2.0-85011105581