Cyr61 Expression Pattern and Association with Clinico-pathological Factors in Patients with Cervical Cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10363059" target="_blank" >RIV/00216208:11140/17:10363059 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/17:10363059
Result on the web
<a href="http://dx.doi.org/10.21873/anticanres.11585" target="_blank" >http://dx.doi.org/10.21873/anticanres.11585</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21873/anticanres.11585" target="_blank" >10.21873/anticanres.11585</a>
Alternative languages
Result language
angličtina
Original language name
Cyr61 Expression Pattern and Association with Clinico-pathological Factors in Patients with Cervical Cancer
Original language description
Background/Aim: The pro-angiogenic Cyr61 protein has been associated with tumorigenesis and cancer progression in different gynecological carcinomas. In this study, we evaluated the potential impact and clinical relevance of Cyr61 expression in patients with primary non-metastatic cervical cancer (CC). Patients and Methods: Cyr61 expression was assessed in tissue specimen of 48 patients with primary CC by immunohistochemical analysis. Expression levels were scored and correlated to clinico-pathological factors and outcome data. Results: High Cyr61 expression levels were present in 54.2% of CC tissues. Associations with histological grade (p=0.030), depth of tumor invasion (p=0.007) and GOG score (p=0.027) were observed. Patients who overexpressed Cyr61 displayed an increased death rate (30.8% vs. 18.2%) and a decreased 5-year-survival (76.9% vs. 86.4%). Conclusion: Our data indicate a potential functional impact of Cyr61 in development and the progression of CC. The definite tumor-relevant function (suppressive/promoting) of Cyr61 in CC and the prognostic relevance of Cyr61 overexpression has to be evaluated in larger cohorts.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Anticancer Research
ISSN
0250-7005
e-ISSN
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Volume of the periodical
37
Issue of the periodical within the volume
5
Country of publishing house
GR - GREECE
Number of pages
6
Pages from-to
2451-2456
UT code for WoS article
000402173300035
EID of the result in the Scopus database
2-s2.0-85019121367