Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F21%3A10426630" target="_blank" >RIV/00216208:11140/21:10426630 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/21:10426630 RIV/00216208:11120/21:43921775 RIV/75010330:_____/21:00013524 RIV/65269705:_____/21:00074468 and 3 more
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=wmrTV-CYVo" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=wmrTV-CYVo</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3892/ol.2021.12859" target="_blank" >10.3892/ol.2021.12859</a>
Alternative languages
Result language
angličtina
Original language name
Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer
Original language description
Colorectal cancer is one of the most frequent cancers and pancreatic adenocarcinoma is among the most fatal and difficult to treat. New prognostic biomarkers are urgently needed to advance the treatment of these malignancies. PRC1, KIF14 and CIT play an important role in cytokinesis, strongly connected with cancer progression, and have prognostic potential. We investigated prognostic relevance of these genes for colorectal and pancreatic cancer. We followed gene expression of PRC1, KIF14 and CIT by qPCR in colorectal carcinomas and paired distant unaffected mucosa from 67 patients and tumors and paired non-neoplastic control tissues from 48 patients with pancreatic adenocarcinoma. The extent of transcript dysregulation between tumor and control tissues and between groups of patients divided by main clinical characteristics was determined. Finally, we evaluated associations of transcript levels in tumors with disease-free interval and overall survival. PRC1, KIF14 and CIT transcripts were overexpressed in tumors compared to control tissues and strongly correlated together in both patient cohorts after correction for multiple testing. However, we have not found significant associations of transcript levels in target genes with survival. Taken together, study shows overexpression and mutual correlation of the followed cytokinesis regulators with no clear prognostic value.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oncology Letters
ISSN
1792-1074
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
2
Country of publishing house
GR - GREECE
Number of pages
12
Pages from-to
598
UT code for WoS article
000667256200001
EID of the result in the Scopus database
2-s2.0-85108587679