The association of taxane resistance genes with the clinical course of ovarian carcinoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10190964" target="_blank" >RIV/00216208:11110/13:10190964 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/13:10190964 RIV/00216208:11120/13:43907530 RIV/00098892:_____/13:#0000604 RIV/00064203:_____/13:10190964 RIV/75010330:_____/13:00010095
Result on the web
<a href="http://dx.doi.org/10.1016/j.ygeno.2013.03.005" target="_blank" >http://dx.doi.org/10.1016/j.ygeno.2013.03.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ygeno.2013.03.005" target="_blank" >10.1016/j.ygeno.2013.03.005</a>
Alternative languages
Result language
angličtina
Original language name
The association of taxane resistance genes with the clinical course of ovarian carcinoma
Original language description
Taxane and platinum-based chemotherapy regimens are standard treatment for advanced ovarian carcinoma. Expression levels of putative markers of taxane resistance in carcinoma tissues and paired peritoneal samples (n = 55) and in 16 samples of ovaries without signs of carcinoma were compared with clinical data and the patients' time to progression. KIF14, PRC1, CIT and ABCC1 genes were significantly overexpressed in carcinomas when compared with normal ovarian tissues, while ABCB1 and CASP9 expression was decreased. Associations of protein expression of the proliferation marker Ki-67 with KIF14, PRC1, ABCB1 and CASP2 were found. Lastly, it was discovered that ABCB1 and CASP2 levels associated with FIGO stage and that the CIT level associated with the time to progression of ovarian carcinoma patients (P < 0.0001). In conclusion, ABCB1, CASP2, KIF14, PRC1 and CIT genes seem to associate with surrogate markers of ovarian carcinoma progression and CIT gene associates with therapy outcome.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Genomics
ISSN
0888-7543
e-ISSN
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Volume of the periodical
102
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
96-101
UT code for WoS article
000322848500004
EID of the result in the Scopus database
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