Gene expression profiling reveals novel candidate markers of ovarian carcinoma intraperitoneal metastasis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F17%3A00011845" target="_blank" >RIV/75010330:_____/17:00011845 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/17:43915892 RIV/00216208:11130/17:10362966 RIV/00216208:11140/17:10362966 RIV/61989592:15110/17:73583818 and 3 more

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687176/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687176/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7150/jca.20766" target="_blank" >10.7150/jca.20766</a>

Result language

angličtina

Original language name

Gene expression profiling reveals novel candidate markers of ovarian carcinoma intraperitoneal metastasis

Original language description

Epithelial ovarian cancer (EOC) has the highest mortality among gynecological carcinomas. The lack of specific markers for prognostic determination of EOC progression hinders the search for novel effective therapies. The aim of the present study was (i) to explore differences in expressions of ATP-binding cassette (ABC) and solute carrier (SLC) transporter genes, genes associated with drug metabolism and cell cycle regulation between control ovarian tissues (n = 14), primary EOCs (n = 44) and intraperitoneal metastases (n = 29); (ii) to investigate associations of gene expression levels with prognosis of patients with intraperitoneal metastases. In all tissue samples, transcript levels of the above target genes were assessed using quantitative real-time PCR. Gene expression levels were compared between particular tissue types and evaluated with regard to progression-free survival (PFS) and drug-resistance status of patients with metastases. Gene expression of ABCA7 significantly increased and that of ESR2 decreased in the order control ovarian tissues - primary EOCs - metastases. High expressions of ABCA2/8/9/10, ABCB1, ABCC9, ABCG2, ATP7A, SLC16A14, and SOD3 genes were significantly associated with longer progression-free survival of patients. In intraperitoneal metastases, expression of all of these genes highly correlated and indicated prognostic profile. Transporters from the ABCA family, ABCG2, and ESR2 are involved mainly in lipid metabolism, membrane transport, and cell proliferation. These processes are thus probably the most important for EOC progression. Based on these results, we have proposed novel markers of ovarian carcinoma progression and metastatic spread which might be potentially useful as therapeutic targets. Their significance should be further explored on a larger independent set of patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30101 - Human genetics

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Cancer

ISSN

1837-9664

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

17

Country of publishing house

AU - AUSTRALIA

Number of pages

9

Pages from-to

3598-3606

UT code for WoS article

000418497000026

EID of the result in the Scopus database

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