Gene expression of membrane transporters: Importance for prognosis and progression of ovarian carcinoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F16%3A00460149" target="_blank" >RIV/68378041:_____/16:00460149 - isvavai.cz</a>

Alternative codes found

RIV/75010330:_____/16:00011285 RIV/00216208:11130/16:10314034 RIV/00216208:11140/16:10314034 RIV/00216208:11120/16:43911064 and 2 more

Result on the web

<a href="http://dx.doi.org/10.3892/or.2016.4599" target="_blank" >http://dx.doi.org/10.3892/or.2016.4599</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/or.2016.4599" target="_blank" >10.3892/or.2016.4599</a>

Result language

angličtina

Original language name

Gene expression of membrane transporters: Importance for prognosis and progression of ovarian carcinoma

Original language description

Membrane transporters (such as ABCs, SLCs and ATPases) act in carcinogenesis and chemoresistance development, but their relevance for prognosis of epithelial ovarian cancer (EOC) remains poorly understood. We evaluated the gene expression profile of 39 ABC and 12 SLC transporters and three ATPases in EOC tissues and addressed their putative role in prognosis and clinical course of EOC patients. Relative gene expression in a set of primary EOC (n=57) and in control ovarian tissues (n=14) was estimated and compared with clinical data and survival of patients. Obtained data were validated in an independent set of patients (n=60). Six ABCs and SLC22A18 gene were significantly overexpressed in carcinomas when compared with controls, while expression of 12 ABCs, five SLCs, ATP7A and ATP11B was decreased. Expression of ABCA12, ABCC3, ABCC6, ABCD3, ABCG1 and SLC22A5 was higher in high grade serous carcinoma compared with other subtypes. ABCA2 gene expression significantly associated with EOC grade in both sets of patients. Notably, expression level of ABCA9, ABCA10, ABCC9 and SLC16A14 significantly associated with progression-free survival (PFS) of the disease in either pilot or validation sets. ABCG2 level associated with PFS in the pooled set of patients. In conclusion, ABCA2, ABCA9, ABCA10, ABCC9, ABCG2 and SLC16A14 present novel putative markers of EOC progression and together with the revealed relationship between ABCA12, ABCC3, ABCC6, ABCD3, ABCG1 and SLC22A5 expression, and high grade serous type of EOC should be further examined by larger follow-up study.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncology Reports

ISSN

1021-335X

e-ISSN

—

Volume of the periodical

35

Issue of the periodical within the volume

4

Country of publishing house

GR - GREECE

Number of pages

12

Pages from-to

2159-2170

UT code for WoS article

000371947700031

EID of the result in the Scopus database

2-s2.0-84958580825