CD44 as a cancer stem cell marker and its prognostic value in patients with ovarian carcinoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10367737" target="_blank" >RIV/00216208:11140/18:10367737 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/18:10367737
Result on the web
<a href="http://dx.doi.org/10.1080/01443615.2017.1336753" target="_blank" >http://dx.doi.org/10.1080/01443615.2017.1336753</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/01443615.2017.1336753" target="_blank" >10.1080/01443615.2017.1336753</a>
Alternative languages
Result language
angličtina
Original language name
CD44 as a cancer stem cell marker and its prognostic value in patients with ovarian carcinoma
Original language description
The aim of our study was to clarify whether the CD44 adhesion molecule as a cancer stem cell marker could also serve as a prognostic factor in patients with epithelial ovarian cancer (EOC). A retrospective study was performed on 87 patients with histologically verified EOC. Specimens of both primary tumour and implantation metastases were tested from 48 of them. CD44 expression was detected by immunohistochemistry. We looked for the cut-off levels of CD44 expression using the Cox regression model. We confirmed statistically significant prognostic factors for overall survival (OS) and disease-free interval (DFI) to be: stage of the disease, postoperative residual tumour and papillary serous histological type. We demonstrated a statistically significant correlation between low CD44 expression and serous papillary carcinoma histotype, tumour recurrence and chemoresistance at a value below 2%. CD44 was neither a prognostic factor of OS nor of DFI.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30214 - Obstetrics and gynaecology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Obstetrics and Gynaecology
ISSN
0144-3615
e-ISSN
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Volume of the periodical
38
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
110-114
UT code for WoS article
000423409800021
EID of the result in the Scopus database
2-s2.0-85027836842