OPG, OPN, EGF and VEGF Levels at Individual Breslow Score Stages in Malignant Melanoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10381478" target="_blank" >RIV/00216208:11140/18:10381478 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/18:10381478
Result on the web
<a href="https://doi.org/10.21873/anticanres.12806" target="_blank" >https://doi.org/10.21873/anticanres.12806</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21873/anticanres.12806" target="_blank" >10.21873/anticanres.12806</a>
Alternative languages
Result language
angličtina
Original language name
OPG, OPN, EGF and VEGF Levels at Individual Breslow Score Stages in Malignant Melanoma
Original language description
BACKGROUND/AIM: Melanoma represents one of the most aggressive forms of cancer. With the rapid increases in the incidence of melanoma in the United States, Australia and Europe over the last decades, melanoma has been considered an epidemic cancer in these areas. The aim of our study was to evaluate the utility of osteoprotegerin (OPG), osteopontin (OPN), epidermal growth factor (EGF) and vascular endothelial growth factor VEGF for the diagnosis and prognosis of melanoma. PATIENTS AND METHODS: Overall, 322 individuals were assessed: 183 melanoma patients and 139 healthy individuals. Melanoma patients were divided into four subgroups according to the Breslow score. OPN, OPG, EGF, and VEGF were determined in each plasma sample. RESULTS: The serum levels of the following biomarkers were statistically significantly higher in the melanoma group compared to the control group: OPG and, OPN (p<0.0001), EGF (p=0.0379). In the first stage, OPG (p=0.0236) and OPN (p=0.0327) showed a statistically significant increase. Concerning positive and negative sentinel node metastases a statistically significant change was observed in: OPN (p<0.0001), EGF (p=0.0114), VEGF (p=0.0114). CONCLUSION: OPG and OPN are promising biomarkers of early-stage melanoma. EGF and VEGF appear to be prognostic biomarkers. Copyright(C) 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Anticancer Research
ISSN
0250-7005
e-ISSN
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Volume of the periodical
38
Issue of the periodical within the volume
8
Country of publishing house
GR - GREECE
Number of pages
5
Pages from-to
4907-4911
UT code for WoS article
000449948300066
EID of the result in the Scopus database
2-s2.0-85050807886