Circulating Cell-Free DNA and Colorectal Cancer: A Systematic Review

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10382385" target="_blank" >RIV/00216208:11140/18:10382385 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/18:00496005 RIV/00216208:11110/18:10382385

Result on the web

<a href="https://doi.org/10.3390/ijms19113356" target="_blank" >https://doi.org/10.3390/ijms19113356</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms19113356" target="_blank" >10.3390/ijms19113356</a>

Result language

angličtina

Original language name

Circulating Cell-Free DNA and Colorectal Cancer: A Systematic Review

Original language description

There is a strong demand for the identification of new biomarkers in colorectal cancer (CRC) diagnosis. Among all liquid biopsy analysts, cell-free circulating DNA (cfDNA) is probably the most promising tool with respect to the identification of minimal residual diseases, assessment of treatment response and prognosis, and identification of resistance mechanisms. Circulating cell-free tumor DNA (ctDNA) maintains the same genomic signatures that are present in the matching tumor tissue allowing for the quantitative and qualitative evaluation of mutation burdens in body fluids. Thus, ctDNA-based research represents a non-invasive method for cancer detection. Among the numerous possible applications, the diagnostic, predictive, and/or prognostic utility of ctDNA in CRC has attracted intense research during the last few years. In the present review, we will describe the different aspects related to cfDNA research and evidence from studies supporting its potential use in CRC diagnoses and the improvement of therapy efficacy. We believe that ctDNA-based research should be considered as key towards the introduction of personalized medicine and patient benefits.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Sciences

ISSN

1422-0067

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

11

Country of publishing house

CH - SWITZERLAND

Number of pages

29

Pages from-to

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UT code for WoS article

000451528500072

EID of the result in the Scopus database

2-s2.0-85055655254