Secretory carcinoma of the major salivary gland: a provincial population-based analysis of clinical behavior and outcomes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F19%3A10386657" target="_blank" >RIV/00216208:11140/19:10386657 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=kWNwQat4tF" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=kWNwQat4tF</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/hed.25536" target="_blank" >10.1002/hed.25536</a>
Alternative languages
Result language
angličtina
Original language name
Secretory carcinoma of the major salivary gland: a provincial population-based analysis of clinical behavior and outcomes
Original language description
Secretory carcinoma (SC) of the salivary gland, previouslyknown as mammary analog SC, is a recently described tumor, occurring principally in the salivary glands, which resembles SC of the breast and includes a characteristic ETV6 gene rearrangement.1 SC may be distinguished from similar tumors such as acinic cell carcinoma, low-grade intraductal carcinoma, and adenocarcinoma, not otherwise specified (NOS) by few or absent zymogen granules or increased extracellular mucin and by immunohistochemical (IHC) positivity for S-100 protein and mammaglobin.1-6 The diagnosis is confirmed by molecular testing for ETV6 rearrangement by fluorescent in situ hybridization (FISH) or reverse transcription polymerase chain reaction (RTPCR).1-3,5,7,8 The most common reported reciprocal translocation is t(12;15) (p13;q25), which leads to fusion of the ETV6 gene on chromosome 12 and the NTRK3 gene on chromosome 15 although other ETV6 translocation partners have been described.9,10 The resulting ETV6 fusion protein has shown transforming activity in several cell lines11 and has been described in a variety of tumors including secretory breast carcinoma,12 infantile fibrosarcoma,13 congenital mesoblastic nephroma,14,15 and radiation-induced thyroid cancer.16 There are now over 200 published cases of SC since the original description by Skálová in 20101; however, most studi s have reevaluated historical files only of acinic cell carcinoma and other mimickers of SC.5,6,8 Although the histopathology, IHC, and cytology of SC are well characterized, relatively few studies have addressed its clinical behavior with long-term follow-up.1-3,6,7,10,17,18 We present a review of the clinical behavior of cases identified through systematic retrospective review of all malignant salivary gland tumors (MSGTs) presenting to a large provincial health care system.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Head & Neck
ISSN
1043-3074
e-ISSN
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Volume of the periodical
41
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1227-1236
UT code for WoS article
000466490000015
EID of the result in the Scopus database
2-s2.0-85059274296