Expression of Serpin B9 as a Prognostic Factor of Colorectal Cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F19%3A10400052" target="_blank" >RIV/00216208:11140/19:10400052 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/19:10400052
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=MHETjU-Enw" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=MHETjU-Enw</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21873/anticanres.13813" target="_blank" >10.21873/anticanres.13813</a>
Alternative languages
Result language
angličtina
Original language name
Expression of Serpin B9 as a Prognostic Factor of Colorectal Cancer
Original language description
BACKGROUND/AIM: Treatment of colorectal cancer (CRC) does not reflect immune interactions between tumours and macro-organisms. Serpin B9 is known as an inhibitor of Granzyme B. The aim of this study was to evaluate the impact of the expression of Serpin B9 in CRC and healthy colon tissue on prognosis. PATIENTS AND METHODS: This retrospective study included 74 CRC patients in all stages. Analysis of gene expression was performed with quantitative polymerase chain reaction with reverse transcription using specific primers and master mix Xceed qPCR SG. Expression was normalized to the reference genes GAPDH, ACTB, and PSMC. RESULTS: Increased expression of Serpin B9 in healthy tissue was significantly associated with longer overall survival (OS). This association was found both in all patients and in the group of patients with distant metastases. CONCLUSION: The presented results support previous evidence of positive influence of the interaction between immune system and tumour on the prognosis of CRC. Copyright(C) 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Anticancer Research
ISSN
0250-7005
e-ISSN
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Volume of the periodical
39
Issue of the periodical within the volume
11
Country of publishing house
GR - GREECE
Number of pages
4
Pages from-to
6063-6066
UT code for WoS article
000496129100025
EID of the result in the Scopus database
2-s2.0-85074687489