lncRNAs in non-malignant tissue have prognostic value in colorectal cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00495541" target="_blank" >RIV/68378041:_____/18:00495541 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3390/ijms19092672" target="_blank" >http://dx.doi.org/10.3390/ijms19092672</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms19092672" target="_blank" >10.3390/ijms19092672</a>

Result language

angličtina

Original language name

lncRNAs in non-malignant tissue have prognostic value in colorectal cancer

Original language description

Although colorectal cancer-CRC is the third most frequent cause of cancer related death in Europe, biomarkers for therapy guidance and prognosis are insufficiently reliable. Long non-coding RNAs are over 200 nucleotides long, they are not translated into proteins but can influence biological processes, as oncogenes, tumour suppressors or regulators of cell proliferation and metastasis development. We aimed to evaluate the prognostic effect of selected lncRNAs in a retrospective study on CRC patients from the Czech Republic. We have measured the expression in paired non-malignant and tumour tissues of CRC patients of nine lncRNAs previously shown to be involved in cancer progression-ANRIL, CCAT1, GAS5, linc-ROR, MALAT1, MIR155HG, PCAT1, SPRY4-IT1 and TUG1. A comparison of expression in tumour and non-malignant mucosa tissues showed significant upregulation of CCAT1 and linc-ROR in tumor tissue and downregulation of ANRIL, MIR155HG and MALAT1. Linc-ROR was significantly associated with the presence of synchronous metastases. For individual tissue types, lower MIR155HG expression in tumor tissue was correlated with both shorter overall survival and shorter disease-free survival. In non malignant tissue expression ratios of CCAT1/ANRIL and CCAT1/MIR155HG were significantly associated with overall survival. Our results revealed that changes in expression of lncRNAs between tumor and non-malignant issues could be used as prognostic biomarkers in CRC patients. Moreover, the ratios of CCAT1 to ANRIL and MIR155HG in non-malignant issue could be used for prognosis assessment. It seems that cancer progression is associated with detrimental system-wide changes in patient tissue, which might govern patient survival even after elimination of tumour.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30219 - Gastroenterology and hepatology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ISSN

1661-6596

e-ISSN

—

Volume of the periodical

19

Issue of the periodical within the volume

9

Country of publishing house

CH - SWITZERLAND

Number of pages

15

Pages from-to

—

UT code for WoS article

000449988100208

EID of the result in the Scopus database

2-s2.0-85053081079