MALAT1 in colorectal cancer: Its implication as a diagnostic, prognostic, and predictive biomarker

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F22%3A00567756" target="_blank" >RIV/68378041:_____/22:00567756 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/22:10446968 RIV/00216208:11140/22:10446968
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S0378111922006102?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0378111922006102?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.gene.2022.146791" target="_blank" >10.1016/j.gene.2022.146791</a>

Result language
angličtina
Original language name
MALAT1 in colorectal cancer: Its implication as a diagnostic, prognostic, and predictive biomarker
Original language description
Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1), originally described as a prognostic biomarker remarkably linked with metastasis potential in lung cancer, has been identified as contributing to many diseases, including colorectal cancer (CRC). This long non-coding RNA (lncRNA) has come to the forefront of lncRNA research for its implications in cancer-related processes, such as cell proliferation and migration. In general, lncRNAs are recognized as enhancers, scaffolds, or decoys for a variety of oncogenes and tumor sup-pressors, although our understanding of lncRNA functions and mechanisms of action is still limited. Nowadays, cancer research is attracted to lncRNAs' ability to improve the early diagnosis of cancer, determine patients' prognosis, or predict therapy outcomes. In this review, we aimed to evaluate recent publications trying to un-cover the cellular mechanisms of MALAT1-mediated regulation, and its potential exploitation in the management of CRC. The conclusions of this review provide robust support for the essential role of MALAT1 in CRC devel-opment and future personalized therapy.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10601 - Cell biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)