MALAT1 in Liquid Biopsy: The Diagnostic and Prognostic Promise for Colorectal Cancer and Adenomas?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F23%3A00580368" target="_blank" >RIV/68378041:_____/23:00580368 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/23:00084121 RIV/00216208:11110/23:10466839 RIV/00216208:11120/23:43925959 RIV/00216208:11140/23:10466839

Result on the web

<a href="https://www.dovepress.com/malat1-in-liquid-biopsy-the-diagnostic-and-prognostic-promise-for-colo-peer-reviewed-fulltext-article-IJGM" target="_blank" >https://www.dovepress.com/malat1-in-liquid-biopsy-the-diagnostic-and-prognostic-promise-for-colo-peer-reviewed-fulltext-article-IJGM</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/IJGM.S420127" target="_blank" >10.2147/IJGM.S420127</a>

Result language

angličtina

Original language name

MALAT1 in Liquid Biopsy: The Diagnostic and Prognostic Promise for Colorectal Cancer and Adenomas?

Original language description

Introduction: The development of colorectal cancer (CRC) is a multistep process accompanied by the accumulation of mutations that start from specific precancerous lesion - colorectal adenomas (CA). CRC incidence and mortality can be reduced by the early identification of these neoplasm. Colonoscopy is the most widely used screening method for CRC identification. Nowadays, clinical research interest is shifting to the use of liquid biopsy that may help with the early diagnosis of CA and CRC. In our previous study, we identified long non-coding RNA MALAT1 gene amplification associated with the development of CA.Methods: This study aimed to describe the potential of MALAT1 expression levels in the adenoma tissue of patients used in the previous study by real-time qPCR. Furthermore, we analysed the plasma samples of an independent group of patients with CA (n=97), CRC (n=101), and cancer-free individuals (CFI, n=48).Results: There was no difference in the MALAT1 expression level between CA patients with or without MALAT1 amplification. However, the plasma MALAT1 expression levels were significantly upregulated in patients with CRC and CA compared to CFI (for both p<0.001). Moreover, a correlation between MALAT1 expression and histological types of adenomas was identified- high-CRC-risk adenomas also displayed the highest MALAT1 expression levels. Furthermore, in CRC patients, MALAT1 levels were associated with a response to therapy. Conclusion: MALAT1 expression levels could serve as a promising circulating biomarker for early CA and CRC diagnosis, and even as a predictor of therapy response in CRC patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/GA22-05942S" target="_blank" >GA22-05942S: Non-invasive detection of circulating mRNA markers in diseases of the colon and rectum</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

INT J GEN MED

ISSN

1178-7074

e-ISSN

1178-7074

Volume of the periodical

16

Issue of the periodical within the volume

sep.

Country of publishing house

NZ - NEW ZEALAND

Number of pages

15

Pages from-to

3517-3531

UT code for WoS article

001050711500001

EID of the result in the Scopus database

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