Late side effects of 3T MRI-guided 3D high-dose rate brachytherapy of cervical cancer Institutional experiences
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F19%3A10400345" target="_blank" >RIV/00216208:11140/19:10400345 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/19:00113450 RIV/00669806:_____/19:10400345
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=osgd-_ZUQo" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=osgd-_ZUQo</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00066-019-01491-0" target="_blank" >10.1007/s00066-019-01491-0</a>
Alternative languages
Result language
angličtina
Original language name
Late side effects of 3T MRI-guided 3D high-dose rate brachytherapy of cervical cancer Institutional experiences
Original language description
Purpose This article reports experiences with 3T magnetic resonance imaging(MRI)-guided brachytherapy (BT) for cervical cancer focusing on late side effects. Methods Between June 2012 and March 2017 a total of 257 uterovaginal BT administrations were performed in 61 consecutive patients with inoperable cervical cancer. All patients were treated with BT combined with external beam radiotherapy. Results The mean HR-CTV (high risk-clinical target volume) D-90 was 87 & x202f;+/- 5.1 & x202f;Gy equivalent dose corresponding to the conventional fractionation using 2 & x202f;Gy per fraction (EQD2, range 70.7-97.9 & x202f;Gy). The mean doses in OAR (organs at risk), namely rectum, sigmoid and bladder were D2 & x202f;cm(rectum)(3)& x202f;= 62.6 & x202f;+/- 6.9 & x202f;Gy EQD2 (range 38.2-77.2 & x202f;Gy), D2 & x202f;cm(sigmoid)(3)& x202f;= 66.2 & x202f;+/- 6.8 & x202f;Gy EQD2 (43.2-78.6 & x202f;Gy) and D2 & x202f;cm(bladder)(3)& x202f;= 75.1 & x202f;+/- 8.3 & x202f;Gy EQD2 (58.2-92.6 & x202f;Gy). There were no signs of late gastrointestinal (GI) toxicity in 49 patients, grade 3 toxicity was seen in 2 patients and grade 4 toxicity in 3 patients. There were no signs of late genitourinary (GU) toxicity in 41 patients, grade 3 toxicity was seen in 4 patients and no signs of grade 4 toxicity were seen. After the treatment, 60 patients (98.4%) achieved locoregional remission. In 54 patients (88.5%) the remission was complete, whereas in 6 patients (9.8%) remission was partial. Conclusion The use of 3T MRI-guided BT leads to achievement of high rates of local control with limited late morbidity as demonstrated in this series of patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Strahlentherapie und Onkologie
ISSN
0179-7158
e-ISSN
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Volume of the periodical
195
Issue of the periodical within the volume
11
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
972-981
UT code for WoS article
000494072900003
EID of the result in the Scopus database
2-s2.0-85069001370