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Late side effects of 3T MRI-guided 3D high-dose rate brachytherapy of cervical cancer Institutional experiences

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F19%3A10400345" target="_blank" >RIV/00669806:_____/19:10400345 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14310/19:00113450 RIV/00216208:11140/19:10400345

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=osgd-_ZUQo" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=osgd-_ZUQo</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00066-019-01491-0" target="_blank" >10.1007/s00066-019-01491-0</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Late side effects of 3T MRI-guided 3D high-dose rate brachytherapy of cervical cancer Institutional experiences

  • Original language description

    Purpose This article reports experiences with 3T magnetic resonance imaging(MRI)-guided brachytherapy (BT) for cervical cancer focusing on late side effects. Methods Between June 2012 and March 2017 a total of 257 uterovaginal BT administrations were performed in 61 consecutive patients with inoperable cervical cancer. All patients were treated with BT combined with external beam radiotherapy. Results The mean HR-CTV (high risk-clinical target volume) D-90 was 87 &amp; x202f;+/- 5.1 &amp; x202f;Gy equivalent dose corresponding to the conventional fractionation using 2 &amp; x202f;Gy per fraction (EQD2, range 70.7-97.9 &amp; x202f;Gy). The mean doses in OAR (organs at risk), namely rectum, sigmoid and bladder were D2 &amp; x202f;cm(rectum)(3)&amp; x202f;= 62.6 &amp; x202f;+/- 6.9 &amp; x202f;Gy EQD2 (range 38.2-77.2 &amp; x202f;Gy), D2 &amp; x202f;cm(sigmoid)(3)&amp; x202f;= 66.2 &amp; x202f;+/- 6.8 &amp; x202f;Gy EQD2 (43.2-78.6 &amp; x202f;Gy) and D2 &amp; x202f;cm(bladder)(3)&amp; x202f;= 75.1 &amp; x202f;+/- 8.3 &amp; x202f;Gy EQD2 (58.2-92.6 &amp; x202f;Gy). There were no signs of late gastrointestinal (GI) toxicity in 49 patients, grade 3 toxicity was seen in 2 patients and grade 4 toxicity in 3 patients. There were no signs of late genitourinary (GU) toxicity in 41 patients, grade 3 toxicity was seen in 4 patients and no signs of grade 4 toxicity were seen. After the treatment, 60 patients (98.4%) achieved locoregional remission. In 54 patients (88.5%) the remission was complete, whereas in 6 patients (9.8%) remission was partial. Conclusion The use of 3T MRI-guided BT leads to achievement of high rates of local control with limited late morbidity as demonstrated in this series of patients.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Strahlentherapie und Onkologie

  • ISSN

    0179-7158

  • e-ISSN

  • Volume of the periodical

    195

  • Issue of the periodical within the volume

    11

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    10

  • Pages from-to

    972-981

  • UT code for WoS article

    000494072900003

  • EID of the result in the Scopus database

    2-s2.0-85069001370