Which serum uric acid levels are associated with increased cardiovascular risk in the general adult population?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F20%3A10411765" target="_blank" >RIV/00216208:11140/20:10411765 - isvavai.cz</a>

Alternative codes found

RIV/00064190:_____/20:N0000016 RIV/00023001:_____/20:00080484 RIV/00216208:11110/20:10411765

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7hWTBmJgEt" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7hWTBmJgEt</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jch.13847" target="_blank" >10.1111/jch.13847</a>

Result language

angličtina

Original language name

Which serum uric acid levels are associated with increased cardiovascular risk in the general adult population?

Original language description

Our aim was to determine the serum uric acid (SUA) levels associated with an increased risk of cardiovascular (CV) and all-cause death in the general adult population. We analyzed data obtained in two independent cross-sectional surveys performed in the Czech Republic in 2006-09 and 2015-18, involving 1% population random samples in nine districts, aged 25-64 years, stratified by age and gender. Ten-year mortality data were obtained in a cohort with examination in 2006-09. Final analyses included 3542 individuals (48.2% men) examined in 2006-09, and 2304 (47.4% men) examined in 2015-18. From a cohort examined in 2006-09, 122 men and 60 women were reported dead (33% and 27% from CV disease). In men, there was no association of baseline SUA levels with baseline SCORE category or 10-year mortality rates. In women, each 10 mu mol/L increase in baseline SUA levels was associated with an increase in baseline SCORE category (P &lt; .001). Receiver operating characteristic curve analyses in women identified the baseline SUA cutoff values discriminating: 1. between low/intermediate and high/very high SCORE categories (309 mu mol/L), 2. CV mortality (325 mu mol/L), and 3. all-cause mortality (298 mu mol/L). After adjusting for confounders including SCORE, Cox regression analysis confirmed that the baseline SUA cutoffs of 309 mu mol/L and 325 mu mol/L were associated with 4-times (P = .010) and 6-times (P = .036) greater risk of CV mortality, whereas the cutoff of 298 mu mol/L was associated with 87% greater risk of all-cause mortality (P = .025). In conclusion, the SUA cutoff value of 309 mu mol/L identified women at high/very high SCORE category and was associated with 4-times greater risk of observed CV mortality over 10 years.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/NV15-27109A" target="_blank" >NV15-27109A: Longitudinal trends in major cardiovascular risk factors and their predictive value in a population random sample, Czech post-MONICA study</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Clinical Hypertension

ISSN

1524-6175

e-ISSN

—

Volume of the periodical

22

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

897-905

UT code for WoS article

000534198500015

EID of the result in the Scopus database

2-s2.0-85083069299