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Salivary Gland Mucinous Adenocarcinoma With Minor (Mammary Analogue) Secretory and Low-Grade In Situ Carcinoma Components Sharing the Same ETV6-RET Translocation and With No Other Molecular Genetic Aberrations Detected on NGS Analysis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F20%3A10414262" target="_blank" >RIV/00216208:11140/20:10414262 - isvavai.cz</a>

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ahNs400vqR" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ahNs400vqR</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1097/PAI.0000000000000806" target="_blank" >10.1097/PAI.0000000000000806</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Salivary Gland Mucinous Adenocarcinoma With Minor (Mammary Analogue) Secretory and Low-Grade In Situ Carcinoma Components Sharing the Same ETV6-RET Translocation and With No Other Molecular Genetic Aberrations Detected on NGS Analysis

  • Original language description

    In 2016, we published in this journal a hitherto undescribed composite salivary gland carcinoma arising in the left parotid gland in a 54-year-old woman. The tumor had a minor mammary analogue secretory carcinoma component (MASC), with a morphologically entirely different mucinous adenocarcinomatous component and a focal, morphologically nondescript, low-grade intraductal (in situ) component. On fluorescence in situ hybridization (FISH), w detected breaks in the ETV6 gene in all the 3 different components. However, RT-PCR failed to reveal an ETV6-NTRK3 fusion. On immunohistochemistry, the entire conventional MASC and patchy mucinous adenocarcinoma tumor cells expressed mammaglobin, while the in situ component was negative. S-100 protein was only expressed by the MASC component. Using the TruSight tumor 170 assay (Illumina, San Diego, CA) on the NextSEq. 500 sequencer (Illumina) following the usual manufacturer&apos;s protocols, we have subsequently further analyzed the in situ and invasive component (MASC mixed with mucinous adenocarcinoma components) separately. This molecular genetic study revealed the same ETV6-RET fusion (exon joining 6 to 12) in both samples. No other molecular genetic aberrations were identified in the applied panel, which consists of 170 genes. The complete list of genes and mutations covered by this assay is shown in Supplemental Table 1.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30109 - Pathology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Applied Immunohistochemistry &amp; Molecular Morphology

  • ISSN

    1541-2016

  • e-ISSN

  • Volume of the periodical

    28

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    4

  • Pages from-to

    "E54"-"E57"

  • UT code for WoS article

    000561310100017

  • EID of the result in the Scopus database

    2-s2.0-85072326403