Primary cutanous desmoplastic melanoma with collagen rosettes and pseudoglandular features
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F21%3A10427571" target="_blank" >RIV/00216208:11140/21:10427571 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=YQZTjT3JEL" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=YQZTjT3JEL</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/DAD.0000000000001809" target="_blank" >10.1097/DAD.0000000000001809</a>
Alternative languages
Result language
angličtina
Original language name
Primary cutanous desmoplastic melanoma with collagen rosettes and pseudoglandular features
Original language description
Cutaneous desmoplastic melanoma (DM) is an uncommon variant of spindle cell melanoma accounting for less than 4% of primary melanomas of the skin. The most common clinical presentation is a firm nonpigmented nodule or plaque on severely sun-damaged skin of elderly male individuals.1 Histologically, DM is a heterogeneous group of melanocytic tumors phenotypically ranging from a scar-like paucicellular proliferation of bland fusiform melanocytes separated by a dense collagenous stroma to high-grade sarcoma-like pleomorphic spindled cells with a variable degree of stromal desmoplasia.2-7 An atypical junctional melanocytic proliferation in the overlying epidermis and lymphocytic aggregates at the periphery of the tumor are often a feature, representing useful diagnostic clues, although the so-called DM arising "de novo" lacks a junctional melanocytic component.8 Histopathological variations in DM include striking neurotropism with perineural and endoneurial invasion (neurotropic desmoplastic melanoma),9 prominent Schwannian and perineural features (neural transformation),10 marked myoid/myofibroblastic differentiation in the stroma, and others.11,12 Molecular analysis of DM reveals a high-mutation burden, ultraviolet (UV) signature, and frequent mutations in NF1 (55%), TP53 (48%), and CDKN2A (47%).13-16 In this article, we present a very unusual case of neurotropic DM with collagen rosette formation, clear cell change, epithelioid cells, and pseudoglandular features.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Dermatopathology
ISSN
0193-1091
e-ISSN
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Volume of the periodical
43
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
221-224
UT code for WoS article
000656633800015
EID of the result in the Scopus database
2-s2.0-85102211739