MITF: a Critical Transcription Factor in Melanoma Transcriptional Regulatory Network
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10191824" target="_blank" >RIV/00216208:11110/13:10191824 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.5772/55191" target="_blank" >http://dx.doi.org/10.5772/55191</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5772/55191" target="_blank" >10.5772/55191</a>
Alternative languages
Result language
angličtina
Original language name
MITF: a Critical Transcription Factor in Melanoma Transcriptional Regulatory Network
Original language description
Melanocytes are specialized cells found predominantly in the skin and eyes that form the pigment melanin. Melanocytes are found also in a benign nevus, a common lesion observed in the skin which is a precursor of malignant melanoma. Sporadic cases of melanoma predominate and can be grouped into four clinical subtypes: acral lentiginous melanoma, nodular melanoma, lentigo maligna and superficial spreading melanoma. About 60-70% of melanomas harbour mutations of the B-RAF gene, while mutations of the N-RAS are present in about 10-25% of all tumors. Many other genes are deregulated during melanoma progression, mainly antiapoptotic genes and gene which are involved in the invasiveness, migration, and metastasis of melanoma, many of which are regulated by MITF-M (microphthalmia-associated transcription factor), a pivotal transcription factor of the melanocyte lineage.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT11229" target="_blank" >NT11229: Transcription factor MITF ? critical regulator of proliferation and viability of melanoma cells and a target of molecular anticancer therapy.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Recent Advances in the Biology, Therapy and Management of Melanoma
ISBN
978-953-51-0976-1
Number of pages of the result
11
Pages from-to
71-81
Number of pages of the book
375
Publisher name
InTech
Place of publication
Rijeka, Croatia
UT code for WoS chapter
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