Transcription physiology of pigment formation in melanocytes: central role of MITF

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A7218" target="_blank" >RIV/00216208:11110/10:7218 - isvavai.cz</a>

Alternative codes found

RIV/00064211:_____/10:#0000066

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Transcription physiology of pigment formation in melanocytes: central role of MITF

Original language description

Melanin production is the primary mechanism protecting human skin against the UV light-induced damage. The polymeric compound melanin is synthesized within melanocytes in the specialized subcellular organelles, termed melanosomes, which are then transferred to surrounding keratinocytes. The genes for melanin synthesis and deposition are coordinately expressed in melanocytes. The transcription factor MITF, which has been reported to activate more than 25 genes in pigment cells, has emerged as an essential regulator not only for melanocyte development, proliferation and survival, but also for the expression of enzymes and structural proteins ensuring the production of melanin. MITF is a transcriptional activator of several genes which encode melanosome-localized proteins involved both in melanin synthesis and in melanosome biogenesis and transport, including genes whose mutations are associated with human oculocutaneous and ocular forms of albinism. Here, we outline the mechanisms of tra

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/NR9319" target="_blank" >NR9319: Altered function and composition of the chromatin-remodeling complex SWI/SNF in the progression of lung carcinoma and melanoma</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental Dermatology

ISSN

0906-6705

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

7

Country of publishing house

DK - DENMARK

Number of pages

11

Pages from-to

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UT code for WoS article

000278796300001

EID of the result in the Scopus database

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