SWI/SNF chromatin remodeling complex is critical for the expression of microphthalmia-associated transcription factor in melanoma cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A7409" target="_blank" >RIV/00216208:11110/10:7409 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

SWI/SNF chromatin remodeling complex is critical for the expression of microphthalmia-associated transcription factor in melanoma cells

Original language description

Transcription factor MITF (microphthalmia-associated transcription factor) plays a central role in the expression of melanocyte-specific genes, lineage determination, and survival of embryonic, adult and malignant melanocytes. Here we show that the expression of MITF requires the presence of active SWI/SNF chromatin remodeling complex, which contains either Brg1 or Brm as a catalytic subunit. In several Brm/Brg1-expressing melanoma cell lines, knockdown of Brg1 severely compromised MITF expression witha concomitant downregulation of MITF targets and decreased cell proliferation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/NR9319" target="_blank" >NR9319: Altered function and composition of the chromatin-remodeling complex SWI/SNF in the progression of lung carcinoma and melanoma</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biochemical and Biophysical Research Communications

ISSN

0006-291X

e-ISSN

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Volume of the periodical

392

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

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UT code for WoS article

000275019800037

EID of the result in the Scopus database

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