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SWI/SNF chromatin remodeling complex is critical for the expression of microphthalmia-associated transcription factor in melanoma cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A7409" target="_blank" >RIV/00216208:11110/10:7409 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    SWI/SNF chromatin remodeling complex is critical for the expression of microphthalmia-associated transcription factor in melanoma cells

  • Original language description

    Transcription factor MITF (microphthalmia-associated transcription factor) plays a central role in the expression of melanocyte-specific genes, lineage determination, and survival of embryonic, adult and malignant melanocytes. Here we show that the expression of MITF requires the presence of active SWI/SNF chromatin remodeling complex, which contains either Brg1 or Brm as a catalytic subunit. In several Brm/Brg1-expressing melanoma cell lines, knockdown of Brg1 severely compromised MITF expression witha concomitant downregulation of MITF targets and decreased cell proliferation.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NR9319" target="_blank" >NR9319: Altered function and composition of the chromatin-remodeling complex SWI/SNF in the progression of lung carcinoma and melanoma</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2010

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biochemical and Biophysical Research Communications

  • ISSN

    0006-291X

  • e-ISSN

  • Volume of the periodical

    392

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    6

  • Pages from-to

  • UT code for WoS article

    000275019800037

  • EID of the result in the Scopus database