The many roles of MITF in melanoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10359663" target="_blank" >RIV/00216208:11110/17:10359663 - isvavai.cz</a>

Result on the web

<a href="https://www.omicsonline.org/open-access/the-many-roles-of-mitf-in-melanoma-2168-9431-1000162.pdf" target="_blank" >https://www.omicsonline.org/open-access/the-many-roles-of-mitf-in-melanoma-2168-9431-1000162.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4172/2168-9431.1000162" target="_blank" >10.4172/2168-9431.1000162</a>

Result language

angličtina

Original language name

The many roles of MITF in melanoma

Original language description

Microphthalmia-associated transcription factor (MITF) plays pivotal role in the maintenance of the melanocyte lineage, differentiation of normal and malignant melanocytes and the survival of melanoma cells. MITF regulates expression of many genes with critical functions in cell differentiation, proliferation, and pro-survival properties. Melanoma is an extremely resilient tumor for which no effective therapy exists when the tumor progresses into metastasis. Melanoma is a heterogenous tumor in which the microheterogeneity arises already in the first stages of the tumor development. Because the dependence of the melanocyte lineage on MITF is critical, MITF is regarded as the paradigmatic lineage-addiction oncogene and its gene is amplified in a smaller subset of melanomas. The level of MITF protein greatly differs among the tumor cells. Intriguingly, low MITF level cells are slowly proliferating but constitute an invasive subpopulation of tumor cells. In this minireview, I briefly discuss the many roles and activities of MITF in melanoma cells and the future prospects for melanoma therapy.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

30204 - Oncology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Single Cell Biology [online]

ISSN

2168-9431

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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