Microphthalmia-associated transcription factor expression levels in melanoma cells contribute to cell invasion and proliferation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295643" target="_blank" >RIV/00216208:11110/15:10295643 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1111/exd.12724" target="_blank" >http://dx.doi.org/10.1111/exd.12724</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/exd.12724" target="_blank" >10.1111/exd.12724</a>

Result language

angličtina

Original language name

Microphthalmia-associated transcription factor expression levels in melanoma cells contribute to cell invasion and proliferation

Original language description

Microphthalmia-associated transcription factor (MITF) is a nodal point in melanoma transcriptional network that regulates dozens of genes with critical functions in cell differentiation, proliferation and survival. Highly variable MITF expression levelsexist in tumor cell subpopulations conferring marked heterogeneity and plasticity in the tumor tissue. A model has been postulated whereby lower MITF levels favour cell invasion and suppress proliferation, whereas high levels stimulate differentiation and proliferation. Additionally, MITF is considered to be a prosurvival gene and a lineage addiction oncogene in melanoma. Herein, we review how MITF expression may affect the melanoma phenotype with consequences on the survival, invasion and metastasis ofmelanoma cells, and we discuss the research challenges.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NT14005" target="_blank" >NT14005: Hedgehog-GLI signalling: an indicator of the tumor biological behavior in melanoma, lung cancer and some other tumors and its blocking as an antitumor therapy</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental Dermatology

ISSN

0906-6705

e-ISSN

—

Volume of the periodical

24

Issue of the periodical within the volume

7

Country of publishing house

DK - DENMARK

Number of pages

4

Pages from-to

481-484

UT code for WoS article

000356693000001

EID of the result in the Scopus database

2-s2.0-84931439294