MITF meets chromatin in melanoma

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12847" target="_blank" >RIV/00216208:11110/12:12847 - isvavai.cz</a>
Result on the web
<a href="https://www.novapublishers.com/catalog/product_info.php?products_id=37164" target="_blank" >https://www.novapublishers.com/catalog/product_info.php?products_id=37164</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
MITF meets chromatin in melanoma
Original language description
SWI/SNF chromatin remodeling complexes contain either Brm (Brahma) or Brg1 (Brahma-related gene 1) as the ATPase subunits. MITF (microphthalmia-associated transcription factor) is a pivotal protein required for the survival and proliferation of normal melanocytes and melanoma cells. MITF activates transcription of many genes regulating proliferation, apoptosis and invasiveness of melanoma cells and is a potential target for gene therapy of melanoma, an aggressive malignant tumor for which no effective therapy exists when metastases occur. Expression of MITF is absolutely dependent on this the SWI/SNF complex, and both Brg1- or Brm-containing complexes are sufficient to support MITF gene transcription. Additionally, especially Brg1 complex seems to support tumor growth even independently of the MITF axis. Thus, SWI/SNF complexes appear to be crucial determinants of melanoma development and progression.
Czech name
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Czech description
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Project
<a href="/en/project/NT11229" target="_blank" >NT11229: Transcription factor MITF ? critical regulator of proliferation and viability of melanoma cells and a target of molecular anticancer therapy.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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