Cancer stem cells and clonal evolution in bone sarcomas

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F21%3A10442743" target="_blank" >RIV/00216208:11140/21:10442743 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/B978-0-12-821666-8.00010-4" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-821666-8.00010-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-821666-8.00010-4" target="_blank" >10.1016/B978-0-12-821666-8.00010-4</a>

Result language
angličtina
Original language name
Cancer stem cells and clonal evolution in bone sarcomas
Original language description
Bone sarcomas are commonly characterized by a high degree of intratumor heterogeneity. The gaining of this diversity in cellular subpopulations involve both a clonal (epi)genetic evolution and a hierarchical organization of these clones which is governed by subsets of cells able to sustain growth. These cancer stem cells (CSCs) subpopulations are responsible for relapses and metastasis due to several stem cell-related properties that endow them with drug resistance and increased invasiveness. Different subsets of CSCs have been identified according to several stem cell-related traits and/or marker expression. Once isolated, CSCs subpopulations must demonstrate a higher tumorigenic and self-renewal potential, when compared to nonselected subpopulations. This chapter focuses on the description of CSCs subpopulations isolated from the most frequent bone sarcoma types. In addition, we recapitulate the molecular signaling that regulates the stemness state and the metastatic dissemination and discuss the dynamics that regulate clonal evolution in bone sarcomas.
Czech name
—
Czech description
—

Project
<a href="/en/project/GA17-17636S" target="_blank" >GA17-17636S: Identification of new prognostic markers and therapeutic target molecules in soft tissue sarcoma</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name
Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside
ISBN
978-0-12-821666-8
Number of pages of the result
21
Pages from-to
371-391
Number of pages of the book
1078
Publisher name
Academic Press
Place of publication
Amsterdam
UT code for WoS chapter
—

Similar results(10)