The Relationship of the Microbiome, Associated Metabolites and the Gut Barrier with Pancreatic Cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F25%3A10496646" target="_blank" >RIV/00216208:11140/25:10496646 - isvavai.cz</a>

Alternative codes found

RIV/75010330:_____/25:00014934

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=78x3s9GJt4" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=78x3s9GJt4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.semcancer.2025.03.002" target="_blank" >10.1016/j.semcancer.2025.03.002</a>

Result language

angličtina

Original language name

The Relationship of the Microbiome, Associated Metabolites and the Gut Barrier with Pancreatic Cancer

Original language description

Pancreatic cancers have high mortality and rising incidence rates which may be related to unhealthy western-type dietary and lifestyle patterns as well as increasing body weights and obesity rates. Recent data also suggest a role for the gut microbiome in the development of pancreatic cancer. Here, we review the experimental and observational evidence for the roles of the oral, gut and intratumoural microbiomes, impaired gut barrier function and exposure to inflammatory compounds as well as metabolic dysfunction as contributors to pancreatic disease with a focus on pancreatic ductal adenocarcinoma initiation and progression. We also highlight some emerging gut microbiome editing techniques currently being investigated in the context of pancreatic disease. Notably, while the gut microbiome is significantly altered in PDAC and its precursor diseases, its utility as a diagnostic and prognostic tool is hindered by a lack of reproducibility and the potential for reverse causality in case-control cohorts. Future research should emphasise longitudinal and mechanistic studies as well as integrating lifestyle exposure and multi-omics data to unravel complex host-microbiome interactions. This will allow for deeper aetiologic and mechanistic insights that can inform treatments and guide public health recommendations.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

<a href="/en/project/NW24-03-00024" target="_blank" >NW24-03-00024: Predictive and prognostic factors for an individualized strategy of pancreatic cancer diagnosis and therapy.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Seminars in Cancer Biology

ISSN

1044-579X

e-ISSN

1096-3650

Volume of the periodical

112

Issue of the periodical within the volume

July

Country of publishing house

GB - UNITED KINGDOM

Number of pages

15

Pages from-to

43-57

UT code for WoS article

001458706900001

EID of the result in the Scopus database

2-s2.0-105001278520