Protein metabolism in guanethidine-treated rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F04%3A00002022" target="_blank" >RIV/00216208:11150/04:00002022 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Protein metabolism in guanethidine-treated rats
Original language description
The aim of the present study was to evaluate using male rats the effect of short-term adrenergic blockade on the rate of whole-body protein turnover and leucine oxidation, and on protein synthesis in specific tissues. Adrenergic blockade was induced by guanethidine (100 mg/b.w. subcutaneously). There was insignificant effect of guanethidine on whole-body proteolysis, protein synthesis, and leucine clearance. However, protein balance was more negative due to the higher difference between protein synthesis and proteolysis in guanethidine treated animals than in controls. In guanethidine treated rats, protein synthesis was higher in gastrocnemius muscle and in the kidneys and lower in liver and spleen. Changes in small intestine and colon were insignificant. It is concluded that adrenergic blockade induced by guanethidine is associated with significant changes in protein metabolism, leucine oxidation and amino acid concentrations in several tissues.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA303%2F03%2F1512" target="_blank" >GA303/03/1512: The possibilities to affect the negative protein balance in severe illness - the effect of proteasome inhibitors</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Experimental Pathology
ISSN
0959-9673
e-ISSN
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Volume of the periodical
85
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
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UT code for WoS article
000223997200003
EID of the result in the Scopus database
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