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Expression of cytoskeletal proteins in hepatic stellate cells isolated from normal and cirrhotic rat liver

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F05%3A00003668" target="_blank" >RIV/00216208:11150/05:00003668 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Expression of cytoskeletal proteins in hepatic stellate cells isolated from normal and cirrhotic rat liver

  • Original language description

    Hepatic stellate cells (HSC) are located in Disse spaces of normal rat liver. In fibrotic liver they become activated, proliferate and they undergo transdifferentiation into myofibroblast-like cells. Changes in the cell phenotype are accompanied by changes in the cellular cytoskeleton. We have studied the expression of alpha-smooth muscle actin and intermediate filament proteins vimentin, desmin and glial fibrillary acidic protein (GFAP) by immunocytochemistry in HSC cultured for 2 or 7 days after isolation. HSC were isolated from normal or CCl4-cirrhotic rat liver.

  • Czech name

    Exprese bílkovin cytoskeletu v jaterních hvězdicových buňkách izolovaných z normálních a cirhotických jater

  • Czech description

    Jaterní hvězdicové buňky se nacházejí v Disseho prostorech normálních jater. Ve fibrotických játrech se aktivují, proliferují a přeměňují se na buňky podobné myofibroblastům. Změny fenotypu jsou provázeny změnami buněčného cytoskeletu. Studovali jsme změny hladkosvalového alfa-aktinu, desminu, vimentinu a GFAP v buňkách izolovaných z normálních i cirhotických jater.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    ED - Physiology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA305%2F03%2F1513" target="_blank" >GA305/03/1513: Expression of connective tissue proteins in rat hepatic stellate cells</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Acta Medica (Hradec Králové)

  • ISSN

    1211-4286

  • e-ISSN

  • Volume of the periodical

    48

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    8

  • Pages from-to

    137-144

  • UT code for WoS article

  • EID of the result in the Scopus database