Interleukin-33, a Novel Member of the IL-1/IL-18 Cytokine Family, in Cardiology and Cardiac Surgery

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F10%3A10061794" target="_blank" >RIV/00216208:11150/10:10061794 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/10:10061794

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Interleukin-33, a Novel Member of the IL-1/IL-18 Cytokine Family, in Cardiology and Cardiac Surgery

Original language description

Interleukin-33 is a newly recognized cytokine of the IL-1 family. Unlike its other members IL-1alfa, IL-1beta and IL-18, interleukin-33 induces predominantly Th2-skewed immune responses. In this context, the effects of IL-33 are mostly anti-inflammatory.However, depending on the actual cytokine and cellular milieu, IL-33 can promote both Th1 and Th2 immune reactions. Most importantly for cardiology and cardiac surgery, IL-33 has emerged to represent the as yet unknown ligand of the orphan receptor ST2.Before the advent of IL-33, the ST2 receptor, currently recognized as the soluble one of its two isoforms, was considered to be an unfavorable prognostic marker in myocardial infarction, congestive heart failure and trauma/sepsis shock patients. Now weknow that IL-33, when bound to the cellular membrane-anchored ST2L isoform of the receptor, can have certain beneficial effects on the aforementioned conditions.10.1055/s-0030-1250436

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Thoracic and Cardiovascular Surgeon

ISSN

0171-6425

e-ISSN

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Volume of the periodical

58

Issue of the periodical within the volume

8

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

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UT code for WoS article

000284624000002

EID of the result in the Scopus database

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